The Dark Side of Humor: Seizure induced by Laughing

Dear Michael, well, didn't we found agreement at least on this very subject:  that however difficult life might be and how long it can take before our efforts in research pay out, threre is always one measure to keep us from giving up. I am talking about human laughter. And it was not only Aristoteles who described human laughter as devine, but it was also identified in several medical studies as promoting health, protecting from various diseases and extending longevity.  I remember when we were riding on the bike through Munich, and you pushed me forward, I felt I should protest against this but in fact I could not, but instead I fell into laughter instinctively. And you said "12 laughters a day keeps the doctor away" ?  And I thought that at least for short term you were right, and it made me feel happy.

But now I red this article in the peer-reviewed Journal of Medical Case Reports (Impact factor 0.4), entitled "Laugh-induced seizure: a case report" by MR Mainali et al from the Health System Department of Medicine in Reading, Pennsylvania. The patient, a 43 caucasian men suffered from "...multiple episodes of seizures, all induced by laughter while watching comedy shows..." (hic!) The patient described the conditions himself as following: "... I started laughing, then my arms started shaking and I felt like my consciousness was being vacuumed away... ". Now I became suspicious, whether I am suffering from the same symptoms. I don't mean that I felt my "...consciousness being vacuumed away..." those days on the bike in Munich, but my arms indeed started to shake a bit when you pushed me forward, and I lost control over the bikes handlebar. So it might have ended dangerous indeed, at least in this situation on the bike.

The authors of the study tested several treatments to help the poor man. The anti-convulosant drug Carbamazepine appeared to prevent the seizures for several month, but according to the FDA this drug has several potential side effects, in particular onto the unborn child of pregnant mothers. The authors concluded in their study that the safest measure against the seizures is by preventing all laugh-inducing situations.  I have to admit, since I started my PhD here in Stockholm, the frequency of laugh-inducing moments went down a little bit. I think to benefit from the healthy effects of laughter, I should instead expose myself intentionally to some extra laugh-inducing situations. As the authors very firmly state at the end of their paper, "... Smiles and laughter are universal human social gestures that involve a complex sequence of facial, pharyngeal and diaphragmatic muscle contractions and help to establish a friendly interaction with other people."  Unfortunatly, they don't make any suggestion about the Comedy that was so efficient in their patient to make him Rolling-on-the-Floor-Laughing.

Take Care, and keep smiling

/ghazal

Iranian Nose Jobs can sabotage Eugenics

Dear Michael,

It is no secret that many Iranian woman do not value their impressive, arian noses very high. In contrast, they tend to follow a very questionable beauty picture that more and more seems to be coined by the Japanese manga figures. For them, a nose is merely anything more than a small ridge to hide the nostrils.
The historical form of Iranian noses, however, is impressive, and if an ancient myth is true that the nose is the main location of human character, than Iranians must have a lot of it (which I believe many of them will agree).

The more I regret that low self-esteem of Iranians when it comes to the shape of their facial “center of gravity”. Iranian woman try to raise their competetiveness when hunting for a good match on the vanity fair, and the men, beeing either the driving force behind this or the obidient donkey, really fall for this.

Here I will explaine to you (based on what I feel as a young woman and what I learned as a young geneticist) the short and the long term consequences of this:

1) In the short term, there will be a constant drop of beauty among Iranian woman, because more and more collect or borrow money to afford a “Nose Job”. So very soon, you will see less and less Iranian ladies whom their strong and proud character is logically located in an equally strong, sharp and expressive nose. We might be confused soon, that Iranians with strong self-esteem decline to western beauty standard, have their face irreversibly damaged only to fill the pockets of those medics, who as all their colleagues from other disciplines agree, are the least qualified ones to distinguish between health and disease, let alone to cure any real sick patient.

The Iranian woman who lost this attribute of an ancient, devine beauty, however, will in fact have better chances to catch a husband and have more children. That is what we know from natural selection of the fittest, which if we like or dislike, becomes the natural selection for the most attractive in the human population.

But, thanks to genetic laws, there is not only hope in sight, as I will explaine in the following, but in the long term these “Iranian Nose Jobs” even have the potential to rescue the Iranian Nose from becomming extinct by natural selection.

2)  Because on the long term,  of course, no plastic surgery can change the genetic code, that over hundreds of generations insured that Iranians, sometimes synonymously with the original Arian nation, where characterized by nice, sharp, impressive noses. No ordinary medic, let alone the half-educted plastic surgeons, have any clue where in the Iranian genome the key for nose shape is hidden, or how this could be manipulated.  So with the current genetic knowledge and the status-quo of molecular technologies, the real treasure of the Iranian nose is still hidden and safely deposited deep in our genome.  So even if all Iranians have their “noses done”, the next and all following generations still carry the fertile seeds to grow proper Iranian noses again.

But this is only half of the truths, the real excitement comes here:  Without plastic surgery, large Iranian noses could in fact become extinct due to genetic admixture from (Iranian x Non-Iranian) partnerships (introgressing the Small-Nose-Gene-Variant from East-Asian or US or Latin-Americans) followed by preferential marriages between the descendents inheriting the Small-Nose-Genes (and consequently growing these dwarf nose variants reminiscent of a Hobbit face). Over just a few generations, there would indeed undergo a natiural selection for the Small-Nose-Gene-Variants, resulting in irreversible loss of the Iranian noses.  But this, in fact, does not happen, thanks to the plastic surgeons and their messing up with the natural link between beauty, genes, and attractiveness.  By virtually “hiding” the real heritable Iranian Nose variant behind a fake, non-heritable small nose, natural selection can not take place any more.

So in the long term, nose jobs to Iranian woman might ensure that the real traditional Iranian nose shape with its distinct and impressive sharpness will always reappear in every new generation. In other words, the plastic surgeons who make money from nose-reducing operations to Iranians on the assembly line, carry out in fact a very efficient sabotage operation against eugenics.